针对安徽某金铅锌复杂多金属硫化矿选矿指标较低、药剂制度复杂且用量大等问题，分析了原矿的矿物组成及矿石性质，并开展了大量探索性试验，最后提出采用磁选脱除磁黄铁矿—金铅混合浮选—金铅分离浮选—尾矿活化选锌的原则流程处理该矿石。结果显示：闭路试验可获得金含量为43.68×10-6，回收率为46.12%的金精矿；铅精矿中金含量为162.00×10-6，回收率为35.39%，铅含量为38.53%，回收率为72.24%，金的累积回收率达81.51%；锌精矿中锌含量为42.79%，回收率为67.51%。与原有选矿工艺相比，新工艺不仅提高了选矿指标还大幅减少了药剂用量。

For a gold-lead-zinc complex polymetallic sulfide ore in Anhui has a problem such as the low ore dressing indexes，the dosage of reagent system is complex and big.The mineral composition and ore characteristic of raw-ore is analyzed and a large number of exploratory experiments is explored.The last put forward the principle of process to deal with the ore by magnetic separation removal of pyrrhotite，gold-lead bulk flotation，gold-lead separation flotation，activation of tailings flotation zinc.By closed circuit texts can obtain the good indicators，and the gold concent rate with the Au grade of 43.67×10-6 and recovery rate of 46.11%；lead concentrate with the Au grade of 162.00×10-6 and recovery rate of 35.39%， Pb grade of 38.53% and recovery rate of 72.24%，the accumulation of the gold recovery rate is 81.50%；zinc concent rate with the Zn grade of 42.76% and recovery rate of 67.46%.This new method has a better index than the traditional process，as it can not only improve dressing indexes，but reduce a lot reagents dosage.