For a gold-lead-zinc complex polymetallic sulfide ore in Anhui has a problem such as the low ore dressing indexes，the dosage of reagent system is complex and big.The mineral composition and ore characteristic of raw-ore is analyzed and a large number of exploratory experiments is explored.The last put forward the principle of process to deal with the ore by magnetic separation removal of pyrrhotite，gold-lead bulk flotation，gold-lead separation flotation，activation of tailings flotation zinc.By closed circuit texts can obtain the good indicators，and the gold concent rate with the Au grade of 43.67×10-6 and recovery rate of 46.11%；lead concentrate with the Au grade of 162.00×10-6 and recovery rate of 35.39%， Pb grade of 38.53% and recovery rate of 72.24%，the accumulation of the gold recovery rate is 81.50%；zinc concent rate with the Zn grade of 42.76% and recovery rate of 67.46%.This new method has a better index than the traditional process，as it can not only improve dressing indexes，but reduce a lot reagents dosage.