With the rapid development of digital mine，3DMine software has been widely used in mine design institutes.However，for multi-layer gently inclined thin ore group，the traditional two-dimensional underground mining development design mode has some problems，such as low design efficiency，heavy workload and difficult to determine the optimal reference location of development shaft.Under the guidance of the concept of synergetic mining，the 3D synergetic design of shaft location was carried out to accurately plan the spatial layout of the development shaft，improve the efficiency of mining design and ensure the effectiveness of the design scheme.Taking Tongkeng zinc polymetallic deposit in Guangxi Huaxi Group as the engineering background，and referring to the traditional two-dimensional transport work calculation model，considering the influence of ore volume and different burial depth on transport work，a three-dimensional transport work calculation model was established based on straight line distance，and then the vertical shaft development arrangement was optimized and the competition problem of transportation work was dealt with cooperatively.According to the determination method of rock movement parameters recommended by Mining Survey Research Institute in Soviet Union，in the Tongkeng zinc polymetallic mine case，the rock is classified into layered rock mass and rock movement characteristics.Combined with the occurrence form，engineering geological condition，hydro-geological condition，surface topography，geological structure，mining method and rock mass mechanical parameters of the orebody，the rock movement angle of the upper，lower and end of the orebody is determined to be 75% with reference to the actual data of the surface rock displacement of similar mines.With the aid of 3DMine software，the scope of rock movement was delineated，and combined with the proposed three-dimensional transport work calculation model，the preliminary selection scheme of shaft development was given.The set pair analysis method was used to optimize the development preliminary selection scheme with four evaluation indexes of safety，resource utilization rate，transportation work and economic investment.The results show that，based on the three-dimensional transportation work calculation model，the optimal scheme is “newly excavated mixed well and using the No.3 and No.4 blind inclined well development scheme”. Results of this study indicate that，based on the three-dimensional transport work calculation model under the straight-line distance，the transportation competition relationship among different buried depths of the seam is coordinated，which makes up for the shortcomings of the transport work calculation model in the development design，and can accurately plan the optimal spatial reference layout location of development shaft from the three-dimensional perspective，thus providing useful reference for development design.